The Titan Krios G4 is Thermo Fisher's premier cryo-electron microscope, purpose-built for single-particle cryo-EM and cryo-tomography at near-atomic resolution. Operating at 300 kV with a Selectris X energy filter and Falcon 4i direct electron detector, it routinely achieves sub-2 Å resolution. Automated data collection and column alignment enable high-throughput structural biology workflows for drug discovery and fundamental research.