Tissue Section (H&E)

Histology

All Specimens

Formalin-fixed paraffin-embedded tissue section with hematoxylin and eosin staining

Stains: he unstained fluorescence masson_trichrome pas silver

Images: 23

Compatible Scopes: 21

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23 images

Normal Human Liver — H&E

Histological section of normal human liver showing hepatocytes arranged in cords separated by sinusoids. Portal triads and central veins visible in the parenchyma.

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Courtesy: Dept. of Histology, Jagiellonian University Medical College

Wikimedia Commons — CC BY-SA 3.0

Kidney Histology — Glomerulus and Tubules

Kidney section showing labeled structures: (1) Glomerulus, (2) proximal convoluted tubule, (3) distal convoluted tubule. Classic renal cortex architecture.

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Labeled educational histology image by Uwe Gille

Wikimedia Commons — CC BY-SA 3.0

Normal Lung — Alveoli

Normal lung parenchyma showing thin-walled alveoli lined by type I and type II pneumocytes. Alveolar septa with capillaries are clearly visible.

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By Yale Rosen — normal alveolar architecture

Wikimedia Commons — CC BY-SA 2.0

Cardiac Muscle Tissue — H&E Section

Light micrograph of cardiac muscle tissue showing branching myocytes with central nuclei and intercalated discs. Striated pattern is visible in longitudinal section.

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Cardiac muscle histology with striations and branching

Wikimedia Commons — CC BY-SA 4.0

Skin Histology — Thick Skin (Epidermis & Dermis)

Histological section of thick skin showing all layers of the epidermis (stratum basale through corneum) and underlying dermis with collagen fibers and blood vessels.

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Educational histology — thick (glabrous) skin

Wikimedia Commons — CC BY-SA 4.0

Brain Tissue — Thalamic Neuron, H&E

Histology of a thalamic neuron showing a large cell body with prominent nucleus, nucleolus, and Nissl substance. Neuropil visible in surrounding tissue.

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Central nervous system histology

Wikimedia Commons — CC BY-SA 4.0

Small Intestine — Villi and Crypts

Low-magnification micrograph of small intestine showing finger-like villi projecting into the lumen, crypts of Lieberkuhn, muscularis mucosae, and submucosa.

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Classic intestinal histology by Nephron

Wikimedia Commons — CC BY-SA 3.0

Lactating Breast Tissue — H&E

Histology of lactating breast showing dilated lobular acini filled with secretory material. Lobular architecture is well-preserved with surrounding stroma.

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Public domain mark — lactating mammary gland

Wikimedia Commons — Public Domain

Thyroid Gland — Colloid Follicles

Cross-section of human thyroid gland showing follicles filled with scalloped colloid and lined by cuboidal follicular epithelium. Scalloping indicates active reabsorption.

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100x magnification, hematoxylin stain

Wikimedia Commons — CC BY 2.0

Pancreas — Islets of Langerhans

Section of human pancreas showing larger islets of Langerhans near the main interlobular ducts. Endocrine islets appear as pale clusters amid darker exocrine acinar tissue.

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Phase contrast, human pancreas

Wikimedia Commons — CC BY 2.0

Invasive Ductal Carcinoma of the Breast

Histopathology of invasive ductal carcinoma (IDC), the most common type of breast cancer. Malignant ductal cells infiltrate the stroma in irregular nests and cords with desmoplastic reaction.

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Most common histotype of breast cancer (~70-80%)

Wikimedia Commons — CC BY-SA 4.0

Lung Adenocarcinoma — Acinar Pattern

Histopathology of lung adenocarcinoma showing an acinar growth pattern. Malignant glands with cytologic atypia infiltrate the lung parenchyma.

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Most common lung cancer subtype in non-smokers

Wikimedia Commons — CC BY 4.0

Colon Adenocarcinoma — Biopsy

High-magnification micrograph of colon adenocarcinoma biopsy showing angulated malignant glands with nuclear hyperchromasia, loss of goblet cells, and stromal desmoplasia.

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H&E stain, by Nephron — colon biopsy

Wikimedia Commons — CC BY-SA 3.0

Liver Cirrhosis — Chronic Alcoholic

Histopathology of chronic alcoholic cirrhosis showing regenerative nodules of hepatocytes surrounded by bridging fibrosis. Normal lobular architecture is completely distorted.

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H&E stain — end-stage liver disease

Wikimedia Commons — CC BY-SA 4.0

Crescentic Glomerulonephritis — High Magnification

High-magnification micrograph of crescentic (rapidly progressive) glomerulonephritis. Epithelial crescents compress the glomerular tuft, indicating severe inflammation.

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Also known as RPGN — medical emergency, by Nephron

Wikimedia Commons — CC BY-SA 3.0

Masson's Trichrome — Human Trachea

Masson's trichrome stained section of human trachea showing pseudostratified ciliated epithelium (red), collagen in the submucosa (blue/green), and cartilage rings.

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Blue = collagen, red = muscle/cytoplasm, black = nuclei

Wikimedia Commons — CC BY-SA 4.0

Renal Corpuscle — PAS Stain

Periodic acid-Schiff (PAS) stained section of a renal corpuscle (glomerulus). PAS highlights basement membranes in magenta, including the glomerular and tubular basement membranes.

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PAS lights up basement membranes — kidney biopsy standard

Wikimedia Commons — CC BY-SA 3.0

Liver — Reticulin (Silver) Stain

Reticulin silver stain of liver showing the reticular fiber framework. Normal liver has a preserved reticulin pattern with 1-2 cell-thick hepatocyte plates. Loss of pattern suggests malignancy.

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Silver/reticulin stain — by Nephron, fatty liver disease context

Wikimedia Commons — CC BY-SA 3.0

Post-Infectious Glomerulonephritis — PAS Stain

Intermediate-magnification micrograph of post-infectious glomerulonephritis (PIGN) with PAS stain. Glomeruli show hypercellularity and endocapillary proliferation with neutrophil infiltration.

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PAS stain, kidney biopsy — by Nephron

Wikimedia Commons — CC BY-SA 3.0

Primary Biliary Cirrhosis — Low Magnification

Low-magnification micrograph of primary biliary cirrhosis (PBC) showing portal inflammation centered on bile ducts, with granulomatous destruction. H&E stain of liver biopsy.

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PBC — autoimmune bile duct destruction, by Nephron

Wikimedia Commons — CC BY-SA 3.0

Colon Adenocarcinoma ex Villous Adenoma

Composite showing villous adenoma (upper left) transitioning to invasive adenocarcinoma (lower right). Demonstrates malignant transformation from precursor polyp.

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Adenoma-carcinoma sequence demonstration

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Cerebellum — Neurofilament Stain

Antibody staining of human cerebellum highlighting phosphorylated neurofilament heavy chain in Purkinje cell axons. Molecular, Purkinje, and granular layers visible.

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Immunohistochemistry — neurofilament antibody staining

Wikimedia Commons — CC BY-SA 3.0

Mucinous Adenocarcinoma of the Colon — H&E

Mucinous adenocarcinoma of the colon showing disruption of the lamina muscularis mucosae by invasive tumor with abundant extracellular mucin pools.

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Mucinous subtype — >50% extracellular mucin

Wikimedia Commons — CC BY-SA 3.0

Compatible Microscopes

Model	Manufacturer	Type	Magnification Range	NA Max	Resolution
SkyScan 1275	Bruker	Micro Ct	-–-×	—	— nm
SkyScan 1273	Bruker	Micro Ct	-–-×	—	— nm
VHX-7000	Keyence	Digital Microscope	0.1–6000×	—	100 nm
DM6 B	Leica Microsystems	Upright Optical	1.25–100×	1.4	200 nm
DMi8	Leica Microsystems	Inverted Optical	2.5–100×	1.47	185 nm
STELLARIS 5	Leica Microsystems	Confocal	5–100×	—	120 nm
Eclipse Ti2	Nikon	Inverted Optical	2–100×	1.45	190 nm
Eclipse Ni	Nikon	Upright Optical	2–100×	1.4	200 nm
A1R HD25	Nikon	Confocal	4–100×	—	140 nm
BX53	Olympus (Evident)	Upright Optical	2–100×	1.4	200 nm
IX83	Olympus (Evident)	Inverted Optical	2–100×	1.4	200 nm
FV4000	Olympus (Evident)	Confocal	4–100×	—	120 nm
nano3DX	Rigaku	X Ray Microscope	-–-×	—	— nm
inspeXio SMX-225CT FPD HR Plus	Shimadzu	Micro Ct	-–-×	—	— nm
Axio Observer 7	Zeiss	Inverted Optical	5–100×	1.4	200 nm
Axio Imager 2	Zeiss	Upright Optical	1.25–100×	1.4	200 nm
LSM 980	Zeiss	Confocal	5–63×	—	120 nm
Primostar 3	Zeiss	Upright Optical	4–100×	1.25	350 nm
Xradia 520 Versa	Zeiss	X Ray Microscope	-–-×	—	— nm
Xradia 620 Versa	Zeiss	X Ray Microscope	-–-×	—	— nm
Xradia 800 Ultra	Zeiss	X Ray Microscope	-–-×	—	— nm

Tissue Section (H&E)